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Metabolic Syndrome and Psychiatric Illness: Interactions, Pathophysiology, Assessment and Treatment, by Scott D Mendelson
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Metabolic syndrome is a set of risk factors that includes: abdominal obesity, a decreased ability to process glucose (insulin resistance), dyslipidemia (unhealthy lipid levels), and hypertension. Patients who have this syndrome have been shown to be at an increased risk of developing cardiovascular disease and/or type 2 diabetes. Metabolic syndrome is a common condition that goes by many names (dysmetabolic syndrome, syndrome X, insulin resistance syndrome, obesity syndrome, and Reaven's syndrome).
This is the first book to fully explain the relationships between psychiatric illness, Metabolic Syndrome, diet, sleep, exercise, medications, and lifestyle choices. Metabolic Syndrome is a major risk factor in Major Depression, Alzheimer's Disease, Sleep Disorders, Sexual Dysfunction, Fibromyalgia, and several other illnesses of psychiatric significance. Conversely, some psychiatric illnesses tend to predispose patients to Metabolic Syndrome. Of further interest is the fact that some of the medications used in the treatment of psychiatric illnesses have been found to cause or exacerbate Metabolic Syndrome.
The author here provides basic information about what genetic predispositions, medical conditions, and lifestyle choices make Metabolic Syndrome more likely to occur. Among the contributing factors that are discussed are genetics, habitual intake of high glycemic index carbohydrates, fructose, saturated fats, trans fatty acids, vitamins, micronutrients, obesity, smoking, and lack of exercise.
The author describes the actual mechanisms by which Metabolic Syndrome progresses and causes damage in the body, including the action of insulin and the pathophysiology of insulin resistance. Details are provided on what occurs in the liver, pancreas, muscle, fat cells, and immune system as Metabolic Syndrome progresses. New findings are presented on fat cells, including the fact that they are beginning to be considered as endocrine cells. There is a substantive discussion of leptin, which is one of the important adipocytokines. Also carbohydrate, 'bad fats', inflammation, oxidative damage, over-stimulation of the 'fight or flight' system, and high levels of the stress hormone cortisol can actually cause the manifestations of Metabolic Syndrome. These explanations set the stage for an explanation of the inter-relationships between Metabolic Syndrome, psychiatric illness, dementia and effects of not only diet and life choices, but also the effects of psychiatric medications.
Finally, there is an important and unique section on the relationship between Metabolic Syndrome and various psychiatric illnesses, and how they exacerbate each other. The significance of Metabolic Syndrome in Major Depression, Bipolar Affective Disorder, Schizophrenia, fibromyalgia and Polycystic Ovary Disease is vast and it is important to realise the effects of psychiatric medications on Metabolic Syndrome. The author discusses antidepressants, mood stabilizers and the new atypical antipsychotics. There are dramatic differences among medications in the way they affect Metabolic Syndrome and pharmaceutical companies will want to promote patient awareness with this book.
- Sales Rank: #2397969 in eBooks
- Published on: 2007-12-19
- Released on: 2007-12-19
- Format: Kindle eBook
Review
"Obesity and diabetes are a huge problem in our society along with depressive illness and anxiety disorders. Metabolic Syndrome and Psychiatric Illness provides a lucid explanation of the emerging story linking psychiatric illnesses to metabolic disorders such as diabetes and obesity. Mendelson shows a deep and scholarly knowledge of his topic, and an ability to explain science in a lucid and highly readable manner. He also offers excellent advice on how to deal with Metabolic Syndrome through behavioral as well as medical treatments." --Bruce McEwen, Ph.D, Alfred E. Mirsky Professor, Head of the Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York
"This book is magnificent. The Metabolic Syndrome, important throughout medicine, is notably relevant for psychiatry. Mendelson, a psychiatrist with a Ph.D. in neuroendocrine research, is ideally suited for the challenge of explicating the linkages. The book ranges broadly, from the fascinating story of how Jerry Reaven uncovered the syndrome, through the molecular underpinnings to clinical ramifications for depression and other psychiatric disorders. Mendelson’s writing is lucid, engaging and carries the reader forward like a fine novelist. A must read for physicians of all specialties." --Solomon H. Snyder, M.D., Distinguished Service Professor of Neuroscience, Pharmacology and Psychiatry, Director of the Department of Neuroscience,Johns Hopkins University School of Medicine, Baltimore, Maryland
" This book is a very timely contribution to the field of psychiatry given the intense interest and controversy surrounding metabolic disorders as co-existing medical conditions with psychotic and mood disorders, as well as iatrogenic consequences of certain psychopharmacological treatments. It contains a wealth of research-based, practical, clinical information about the metabolic syndrome and its relevance to many psychiatric disorders and psychotropic agents. It is the most comprehensive and well-referenced guide about this topic I have read. Despite my familiarity with this area of research, I learned many important new facts from reading this well-written book. I recommend it as a unique resource not only for physicians but for all mental health professionals." --Henry A. Nasrallah, M.D., Professor of Psychiatry, Neurology and Neuroscience Director of the Schizophrenia Research Program, University of Cincinnati College of Medicine, Ohio
Most helpful customer reviews
5 of 5 people found the following review helpful.
A Terrific Reference For All Members Of Medicinal Practice
By John Tierney
I have read all three of Dr. Mendelson's works, and I was tremendously impressed by his 'Beyond Alzheimer's ..' When I discovered 'Metabolic Syndrome and Psychiatric Illness,' I knew I had to have it. In this work, Dr. Mendelson takes you deeper into the realities that began with the fifteen cent hamburger, expansive methods
the populace found to be sedentary, and why, when you're out shopping, you witness so many potential diabetes II and cardiac artery disease candidates. Each chapter ends with a robust listing of sources Dr. Mendelson utilized in constructing his tome. Frankly, I saw a few things about me in his writing; things which I have begun to change to regain good feelings about myself and how I got where I am. It is also becoming very apparent why insurance companies, with the extended actuary tables for men and women, are pushing hard to implement premiums or no premiums on individuals who are living life in the 'fat lane' and feeling assured that there is a medication for everything. This book should open many eyes, and many consciences about themselves and the life that lies ahead. The book is not your ordinary rudimentary exercise in wellness and fitness. Rather, it is an amazing journey into 50 years of American life that that the human body never expected to be subjected to.
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